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Nonetheless, considerable concerns arise regarding the specificity of NERNST due to its dependence on a redox-sensitive green fluorescent protein (roGFP2) reporter, which is known to efficiently equilibrate with the glutathione redox couple in vivo 19,20,21,22

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If testing reveals unusually high vitamin B12 concentrations, you and your healthcare provider can work together to identify potential underlying causes and determine an appropriate next step or treatment plan